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Take disopyramide exactly as directed by your doctor even though you may feel well. Do not take more medicine than ordered.

For patients taking the extended-release capsules :

• Swallow the capsule whole without breaking, crushing, or chewing.

For patients taking the extended-release tablets:

• Do not crush or chew the tablet.

This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times day and night. For example, if you are to take four doses a day, the doses should be spaced about 6 hours apart. If this interferes with your sleep or other daily activities, or if you need help in planning the best times to take your medicine, check with your health care professional.

Dosing

The dose of disopyramide will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of disopyramide. If your dose is different, do not change it unless your doctor tells you to do so.

The number of tablets or capsules that you take depends on the strength of the medicine.

• For treatment of arrhythmias:
  • For short-acting oral dosage form (capsules):
    • Adults 100 to 150 mg taken every six to eight hours.
    • Children Dose is based on body weight and age and must be determined by your doctor. The dose is usually 6 to 30 mg per kilogram (kg) (2.73 to 13.64 mg per pound) of body weight per day. This dose is evenly divided and taken every six hours.
  • For long-acting oral dosage forms (extended-release capsules or tablets):
    • Adults 200 or 400 mg every twelve hours.
    • Children Use is not recommended.

Missed dose

If you miss a dose of this medicine, take it as soon as possible unless the next scheduled dose is in less than 4 hours. If you do not remember until later, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For disopyramide, the following should be considered:

Allergies Tell your doctor if you have ever had any unusual or allergic reaction to disopyramide. Also tell your health care professional if you are allergic to any other substance, such as foods, preservatives, or dyes.

Pregnancy Disopyramide has not been studied in pregnant women. However, use of disopyramide in a small number of pregnant women seems to show that this medicine may cause contractions of the uterus. Studies in animals have shown that disopyramide increases the risk of miscarriages. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding Disopyramide passes into breast milk.

Children This medicine has been tested in children and has not been shown to cause different side effects or problems than it does in adults.

Older adults Some side effects, such as difficult urination and dry mouth, may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of disopyramide.

Other medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking disopyramide, it is especially important that your health care professional know if you are taking any of the following:

• Antidepressants, tricyclic, such as amitriptyline (e.g., Elavil), clomipramine (e.g., Anafranil), desipramine (e.g., Norpramin), doxepin (e.g., Sinequan), imipramine (e.g., Tofranil), and nortriptyline (e.g., Pamelor) or
• Astemizole (e.g., Hismanal) or
• Chloroquine (e.g., Aralen) or
• Clarithromycin (e.g., Biaxin) or
• Cisapride (e.g., Propulsid) or
• Diphenhydramine (e.g., Benadryl) or
• Erythromycin (e.g., Erythrocin, Erytab) or
• Fludrocortisone (e.g., Florinef) or
• Halofantrine (e.g., Halfan) or
• Haloperidol (e.g., Haldol) or
• Indapamide (e.g., Lozol) or
• Maprotiline (e.g., Ludiomil) or
• Other heart medicine, including amiodarone (e.g., Cordarone); bepridil (e.g., Bepadin, Vascor); beta-adrenergic blocking agents, such as propranolol (e.g., Inderal) or sotalol (e.g., Betapace, Sotacor); diltiazem (e.g., Cardizem); encainide (e.g., Encaid); flecainide (e.g., Tambocor); ibutilide (e.g., Corvert); lidocaine (e.g., Xylocaine); procainamide (e.g., Procanbid); propafenone (e.g., Rythmol); quinidine (e.g., Quinidex); tocainide (e.g., Tonocard); and verapamil (e.g., Calan, Isoptin) or
• Pentamidine (e.g., NebuPent, Pentam) or
• Phenothiazines (chlorpromazine [e.g., Thorazine], prochlorperazine [e.g., Compazine], thioridazine [e.g., Mellaril]) or
• Pimozide (e.g., Orap) or
• Risperidone (e.g., Risperdal) or
• Sparfloxacin (e.g., Zagam) or
• Tamoxifen (e.g., Nolvadex) or
• Thiothixene (e.g., Navane) or
• Trimethoprim and sulfamethoxazole combination (e.g., Bactrim, Septra) Effects on the heart may be increased

• Diabetes mellitus (sugar diabetes) Disopyramide may cause low blood sugar

• Difficult urination or
• Enlarged prostate Disopyramide may cause difficult urination

• Electrolyte disorders Disopyramide may worsen heart rhythm problems

• Glaucoma (history of) or
• Myasthenia gravis Disopyramide may aggravate these conditions

• Kidney disease or
• Liver disease Effects may be increased because of slower removal of disopyramide from the body

• Low blood pressure or
• Other heart disorders Effects of disopyramide on the heart may make these conditions worse

• Malnutrition, long term Disopyramide may cause low blood sugar