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Take primidone every day in regularly spaced doses as ordered by your doctor . This will provide the proper amount of medicine needed to prevent seizures.

Dosing

The dose of primidone will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of primidone. If your dose is different, do not change it unless your doctor tells you to do so.

The number of tablets or teaspoonfuls of suspension that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on your special needs.

• For oral dosage forms (chewable tablets, tablets or suspension):
  • For epilepsy:
    • Adults, teenagers, and children 8 years of age or older At first, 100 or 125 milligrams (mg) once a day at bedtime. Your doctor may increase your dose if needed. However, the dose is usually not more than 2000 mg a day.
    • Children up to 8 years of age At first, 50 mg once a day at bedtime. Your doctor may increase your dose if needed.

Missed dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is within an hour of your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store the tablet form of this medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Keep the liquid form of this medicine from freezing.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For primidone, the following should be considered:

Allergies Tell your doctor if you have ever had any unusual or allergic reaction to primidone or to any barbiturate medicine (for example, amobarbital, butabarbital, pentobarbital, phenobarbital, secobarbital). Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy Although most mothers who take medicine for seizure control deliver normal babies, there are reports of increased birth defects when these medicines are used during pregnancy. Newborns whose mothers were taking primidone during pregnancy have been reported to have bleeding problems. It is not definitely known if any of these medicines are the cause of such problems.

Breast-feeding Primidone passes into the breast milk and may cause unusual drowsiness in nursing babies. It may be necessary for you to take another medicine or to stop breast-feeding during treatment. Be sure you have discussed the risks and benefits of the medicine with your doctor.

Children Unusual excitement or restlessness may occur in children, who are usually more sensitive than adults to these effects of primidone.

Older adults Unusual excitement or restlessness may occur in elderly patients, who are usually more sensitive than younger adults to these effects of primidone.

Other medicines Although certain medicines should not be used together at all, in other cases 2 different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking primidone it is especially important that your health care professional know if you are taking any of the following:

• Adrenocorticoids (cortisone-like medicines) or
• Anticoagulants (blood thinners) Use with primidone may decrease the effects of these medications, and the amount of medicine you need to take may change

• Central nervous system (CNS) depressants (medicine that causes drowsiness) Using these medicines with primidone may increase the CNS and other depressant effects

• Oral contraceptives (birth control pills) containing estrogen Primidone may decrease the effectiveness of these oral contraceptives, and you may need to change to a different type of birth control

• Other anticonvulsants (seizure medicine) A change in the pattern of seizures may occur; close monitoring of blood levels of both medications is recommended. Use of valproic acid with primidone may cause increased CNS depression and other serious side effects

• Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegiline [e.g., Eldepryl], tranylcypromine [e.g., Parnate]) Taking primidone while you are taking or within 2 weeks of taking monoamine oxidase (MAO) inhibitors may prolong the effects of primidone and may change the pattern of seizures

• Asthma, emphysema, or chronic lung disease Primidone may cause serious problems in breathing

• Hyperactivity (in children) or
• Kidney disease or
• Liver disease Primidone may make the condition worse

• Porphyria Primidone should not be used when this medical problem exists because it may make the condition worse