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Take this medicine exactly as directed by your doctor. Do not take more or less of it, and do not take it more often than your doctor ordered. The exact amount of medicine you need has been carefully worked out. Taking too much may increase the chance of side effects, while taking too little may not improve your condition.

It is best to take this medicine at the same time each day. If you have been directed to take the medicine once a day, you may take it either in the morning or in the evening.

Bicalutamide and nilutamide may be taken with food or on an empty stomach.

A nonsteroidal antiandrogen is often used together with another medicine, which is given by injection. It is very important that the two medicines be used as directed. Follow your doctor's instructions very carefully about when to use these medicines.

Unwanted effects, including hot flashes and decreased sexual ability, may occur during treatment for prostate cancer. Also, symptoms that often occur in men with prostate cancer, including difficult or painful urination, bloody urine, and urinary tract infections, may occur or continue to occur for a while, until your condition starts to improve. It is very important that you continue to take the medicine, even if it causes side effects or if you start to feel better. Do not stop taking this medicine without first checking with your doctor.

If you vomit shortly after taking a dose of this medicine, check with your doctor. You will be told whether to take the dose again or to wait until the next scheduled dose.

Dosing

The doses of these medicines will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The number of capsules or tablets that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on which of these medicines you are taking.

For bicalutamide
• For the oral dosage form (tablets):
  • For prostate cancer:
    • Adults 50 milligrams (mg) (one tablet) once a day.
    • Children It is unlikely that bicalutamide would be needed to treat cancer of the prostate in a child. If a child needs this medicine, the dose would have to be determined by the doctor.

For flutamide
• For oral dosage forms (capsules or tablets):
  • For prostate cancer:
    • Adults 250 milligrams (mg) (two 125-mg capsules or one 250-mg tablet) every eight hours.
    • Children It is unlikely that flutamide would be needed to treat cancer of the prostate in a child. If a child needs this medicine, the dose would have to be determined by the doctor.

For nilutamide
• For the oral dosage form (tablets):
  • For prostate cancer:
    • Adults 300 milligrams (mg) (six 50-mg tablets) once a day for the first thirty days, then 150 mg (three 50-mg tablets) once a day.
    • Children It is unlikely that nilutamide would be needed to treat cancer of the prostate in a child. If a child needs this medicine, the dose would have to be determined by the doctor.

Missed dose

If you miss a dose of this medicine, take it as soon as possible.

For bicalutamide or nilutamide: If you do not remember your missed dose until the next day, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

For flutamide: If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For the nonsteroidal antiandrogens, the following should be considered:

Allergies Tell your doctor if you have ever had any unusual or allergic reaction to any of the nonsteroidal antiandrogens. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Fertility

Nonsteroidal antiandrogens, and other treatments for prostate cancer that are used together with these medicines, may cause low sperm counts or otherwise decrease a man's ability to father a child. In some cases, these effects may be permanent. Men who wish to have children should discuss this with their doctors before starting treatment.

Pregnancy Nonsteroidal antiandrogens are usually given to men. However, if one of these medicines is needed by a woman, it is very important that an effective method of avoiding pregnancy be used during treatment. Because these medicines block the effect of the male hormone, testosterone, they may interfere with the normal development of a male fetus.

Breast-feeding Nonsteroidal antiandrogens are usually given to men, and it is not known whether any of these medicines passes into breast milk. However, nonsteroidal antiandrogens can cause serious side effects. Therefore, if a woman needs one of these medicines, she should not breast-feed during treatment.

Children Studies with the nonsteroidal antiandrogens have been done only in adults, and there is no specific information comparing the use of these medicines in children with use in other age groups. There is a chance that a nonsteroidal antiandrogen could interfere with the development of boys. However, cancer of the prostate gland usually occurs in middle-aged or older men, so it is very unlikely that a child would need these medicines.

Older adults Nonsteroidal antiandrogens have been tested in elderly people and have not been shown to cause different side effects or problems than they do in younger adults.

Race

A serious side effect of nilutamide that affects the lungs may be more likely to occur in Asian patients than in Caucasian patients.

Other medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking a nonsteroidal antiandrogen, it is especially important that your health care professional know if you are taking any of the following:

• Anticoagulants such as warfarin (e.g., Coumadin) Bicalutamide,flutamide, or nilutamide may increase the effects of the anticoagulant. Your doctor may recommend having your blood tested more often so that the dose of anticoagulant can be changed if necessary

• Phenytoin (e.g., Dilantin) or
• Theophylline (e.g., Theo-Dur; Theolair) Nilutamide may increase the blood levels of these medicines in your body, which can increase the risk of serious side effects

Also tell your doctor if you smoke tobacco. Tobacco smoking may increase the risk of a rare side effect of flutamide.

• Certain blood deficiencies or disorders or
• Tobacco smoking Increased risk of anemia, other blood disorders, and jaundice
• Liver disease The chance of serious side effects may be increased
• Lung disease or other breathing problems One side effect of nilutamide can make your condition worse; your doctor may want to select a different antiandrogen